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RAB11FIP1

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GENERAL INFORMATION

Gene name

 RAB11FIP1

Gene description

 RAB11 family interacting protein 1 (class I)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 4 antibodies.
CAB017037 , HPA023904 , HPA024010 , HPA025960
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles.

Main location

 Vesicles (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017037 A-431 Vesicles
CAB017037 U-2 OS Vesicles
HPA023904 A-431 Vesicles
HPA023904 U-2 OS Vesicles
Cytosol
HPA023904 U-251 MG Vesicles
HPA024010 A-431 No staining    
HPA024010 CACO-2 Vesicles Intensity
HPA024010 U-2 OS Vesicles
Cytosol
HPA025960 A-431 Vesicles
HPA025960 U-2 OS Vesicles
HPA025960 U-251 MG No staining    

GENE INFORMATION

Gene name

 RAB11FIP1 (HGNC Symbol)

Synonyms

 FLJ22524, FLJ22622, Rab11-FIP1, RCP

Description

 RAB11 family interacting protein 1 (class I) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 37858618 - 37899467

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156675 (version 83.38)

Entrez gene

 80223

UniProt

 Q6WKZ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6WKZ4

Antibodypedia

 RAB11FIP1 antibodies

PROTEIN BROWSER
RAB11FIP1-001
RAB11FIP1-002
RAB11FIP1-006
RAB11FIP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB11FIP1-001
ENSP00000287263
ENST00000287263
Q6WKZ4 [Direct mapping]
Rab11 family-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030670 [phagocytic vesicle membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045055 [regulated secretory pathway]
GO:0055037 [recycling endosome]
GO:0070164 [negative regulation of adiponectin secretion]
Show all
 649 aa
71 kDa 		No 0
RAB11FIP1-002
ENSP00000331342
ENST00000330843
Q6WKZ4 [Direct mapping]
Rab11 family-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030670 [phagocytic vesicle membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045055 [regulated secretory pathway]
GO:0055037 [recycling endosome]
GO:0070164 [negative regulation of adiponectin secretion]
Show all
 1283 aa
137.2 kDa 		No 0
RAB11FIP1-006
ENSP00000430680
ENST00000524118
Q6WKZ4 [Direct mapping]
Rab11 family-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0030670 [phagocytic vesicle membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045055 [regulated secretory pathway]
GO:0055037 [recycling endosome]
GO:0070164 [negative regulation of adiponectin secretion]
Show all
 439 aa
47.7 kDa 		No 0
RAB11FIP1-008
ENSP00000430009
ENST00000522727
E7EX40 [Direct mapping]
Rab11 family-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0017137 [Rab GTPase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045055 [regulated secretory pathway]
Show all
 501 aa
54.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.