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Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Method

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Method

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Searches

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Detectable

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MS4A1
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    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MS4A1

Gene description

Membrane-spanning 4-domains, subfamily A, member 1

Protein class

CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (tonsil, lymph node, spleen, appendix)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, appendix, spleen, lymph node)

Protein evidence

Evidence at protein level

Protein expression

Selective membranous and cytoplasmic expression in leukocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA014341 , HPA014391 , CAB000015
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, lymph node, spleen, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, appendix, spleen, lymph node)

GENE INFORMATION

Gene name

MS4A1 (HGNC Symbol)

Synonyms

B1, Bp35, CD20, MS4A2

Description

Membrane-spanning 4-domains, subfamily A, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.2

Chromosome location (bp)

60455752 - 60470760

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156738 (version 83.38)

Entrez gene

931

UniProt

P11836 (UniProt - Evidence at protein level)

neXtProt

NX_P11836

Antibodypedia

MS4A1 antibodies

PROTEIN BROWSER

MS4A1-001
MS4A1-002
MS4A1-003
MS4A1-006
MS4A1-007
MS4A1-008
MS4A1-201
MS4A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MS4A1-001
ENSP00000433277
ENST00000534668
P11836 [Direct mapping]
B-lymphocyte antigen CD20
A0A024R507 [Target identity:100%; Query identity:100%]
Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a
Show all
CD markers
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0023026 [MHC class II protein complex binding]
GO:0042100 [B cell proliferation]
GO:0070062 [extracellular exosome]
Show all
297 aa
33.1 kDa
No 5
MS4A1-002
ENSP00000433519
ENST00000532073
E9PKH8 [Direct mapping]
B-lymphocyte antigen CD20
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
284 aa
31.6 kDa
No 3
MS4A1-003
ENSP00000432270
ENST00000528313
P11836 [Direct mapping]
B-lymphocyte antigen CD20
Show all
CD markers
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0023026 [MHC class II protein complex binding]
GO:0042100 [B cell proliferation]
GO:0070062 [extracellular exosome]
Show all
130 aa
14.6 kDa
No 0
MS4A1-006
ENSP00000437002
ENST00000533306
E9PPL6 [Direct mapping]
B-lymphocyte antigen CD20
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
123 aa
13.7 kDa
No 2
MS4A1-007
ENSP00000433179
ENST00000524807
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
7 aa
0.8 kDa
No 0
MS4A1-008
ENSP00000432219
ENST00000532491
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
6 aa
0.7 kDa
No 0
MS4A1-201
ENSP00000314620
ENST00000345732
P11836 [Direct mapping]
B-lymphocyte antigen CD20
A0A024R507 [Target identity:100%; Query identity:100%]
Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a
Show all
CD markers
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0016021 [integral component of membrane]
GO:0023026 [MHC class II protein complex binding]
GO:0042100 [B cell proliferation]
GO:0070062 [extracellular exosome]
Show all
297 aa
33.1 kDa
No 5
MS4A1-202
ENSP00000374589
ENST00000389939
P11836 [Direct mapping]
B-lymphocyte antigen CD20
A0A024R507 [Target identity:100%; Query identity:100%]
Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a
Show all
CD markers
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006959 [humoral immune response]
GO:0016021 [integral component of membrane]
GO:0023026 [MHC class II protein complex binding]
GO:0042100 [B cell proliferation]
GO:0070062 [extracellular exosome]
Show all
297 aa
33.1 kDa
No 5

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The Human Protein Atlas project is funded
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