Cell atlas - SASS6 - The Human Protein Atlas

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SASS6

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule organizing center

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	SASS6
Gene description	SAS-6 centriolar assembly protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubule organizing center. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028187
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubule organizing center. In addition localized to the cytosol.

Main location

Microtubule organizing center (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028187	U-2 OS	Microtubule organizing center
	HPA028187	U-2 OS	Cytosol
	HPA028187	U-251 MG	Microtubule organizing center
	HPA028187	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SASS6 (HGNC Symbol)
Synonyms	DKFZp761A078, FLJ22097, SAS-6, SAS6
Description	SAS-6 centriolar assembly protein (HGNC Symbol)
Entrez gene summary	SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) [PubMed 17681132].[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	100083563 - 100132955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156876 (version 83.38)
Entrez gene	163786
UniProt	Q6UVJ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UVJ0
Antibodypedia	SASS6 antibodies

PROTEIN BROWSER

SASS6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SASS6-001 ENSP00000287482 ENST00000287482	Q6UVJ0 [Direct mapping] Spindle assembly abnormal protein 6 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0007099 [centriole replication] GO:0051298 [centrosome duplication] GO:0098536 [deuterosome] Show all	657 aa 74.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.