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Most of the cancer tissues displayed moderate nuclear and/or cytoplasmic positivity, often in a fraction of tumor cells. Several renal, pancreatic, liver and stomach cancers were negative.
GENE INFORMATION
Gene name
ZIC3 (HGNC Symbol)
Synonyms
HTX, HTX1, ZNF203
Description
Zic family member 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001947 [heart looping] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007368 [determination of left/right symmetry] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0035019 [somatic stem cell population maintenance] GO:0035469 [determination of pancreatic left/right asymmetry] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0071907 [determination of digestive tract left/right asymmetry] GO:0071910 [determination of liver left/right asymmetry]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001947 [heart looping] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007368 [determination of left/right symmetry] GO:0007389 [pattern specification process] GO:0009952 [anterior/posterior pattern specification] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0035019 [somatic stem cell population maintenance] GO:0035469 [determination of pancreatic left/right asymmetry] GO:0035545 [determination of left/right asymmetry in nervous system] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0071907 [determination of digestive tract left/right asymmetry] GO:0071910 [determination of liver left/right asymmetry]
