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ZIC3

GENERAL INFORMATION

Gene name

 ZIC3

Gene description

 Zic family member 3

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, testis)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA052936
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 ZIC3 (HGNC Symbol)

Synonyms

 HTX, HTX1, ZNF203

Description

 Zic family member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q26.3

Chromosome location (bp)

 137566142 - 137577691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156925 (version 83.38)

Entrez gene

 7547

UniProt

 O60481 (UniProt - Evidence at protein level)

neXtProt

 NX_O60481

Antibodypedia

 ZIC3 antibodies

PROTEIN BROWSER
ZIC3-001
ZIC3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZIC3-001
ENSP00000359638
ENST00000370606
O60481 [Direct mapping]
Zinc finger protein ZIC 3
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001947 [heart looping]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007368 [determination of left/right symmetry]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0035019 [somatic stem cell population maintenance]
GO:0035469 [determination of pancreatic left/right asymmetry]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0071907 [determination of digestive tract left/right asymmetry]
GO:0071910 [determination of liver left/right asymmetry]
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 457 aa
50 kDa 		No 0
ZIC3-003
ENSP00000287538
ENST00000287538
O60481 [Direct mapping]
Zinc finger protein ZIC 3
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001947 [heart looping]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007368 [determination of left/right symmetry]
GO:0007389 [pattern specification process]
GO:0009952 [anterior/posterior pattern specification]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0035019 [somatic stem cell population maintenance]
GO:0035469 [determination of pancreatic left/right asymmetry]
GO:0035545 [determination of left/right asymmetry in nervous system]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0071907 [determination of digestive tract left/right asymmetry]
GO:0071910 [determination of liver left/right asymmetry]
Show all
 467 aa
50.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.