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Many malignant melanomas, colorectal and ovarian cancers along with a few prostate, urothelial and stomach cancers displayed moderate to strong cytoplasmic with additional membranous staining in some cases. Remaining malignant cells were weakly stained or negative.
Most malignant tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in many cases. A single case each of malignant melanoma, lung, renal and pancreatic cancer displayed strong positivity. Malignant lymphomas, gliomas, skin, testicular malignancies and cancers of uterine cervix were negative.
GENE INFORMATION
Gene name
GALK2 (HGNC Symbol)
Synonyms
GK2
Description
Galactokinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]