Cell atlas - GALK2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GALK2
Gene description	Galactokinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Mouse	Localized to the Golgi apparatus in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048267
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA048267	HeLa	No staining
HPA048267	PC-3	Nucleoplasm
HPA048267	PC-3	Cytosol
HPA048267	U-2 OS	No staining

MOUSE CELLS

Main location

Golgi apparatus

Additional location

Nucleoplasm, Cytosol

Mouse gene

ENSMUSG00000027207 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA048267	NIH 3T3	Nucleoplasm
		Golgi apparatus
		Cytosol

GENE INFORMATION
Gene name	GALK2 (HGNC Symbol)
Synonyms	GK2
Description	Galactokinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Chromosome	15
Cytoband
Chromosome location (bp)	49155656 - 49367869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156958 (version 83.38)
Entrez gene	2585
UniProt	Q01415 (UniProt - Evidence at protein level)
neXtProt	NX_Q01415
Antibodypedia	GALK2 antibodies

PROTEIN BROWSER

GALK2-001	GALK2-002	GALK2-003	GALK2-005	GALK2-006	GALK2-015	GALK2-016	GALK2-019	GALK2-020	GALK2-021	GALK2-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALK2-001 ENSP00000316632 ENST00000327171	Q01415 [Direct mapping] N-acetylgalactosamine kinase Show all	Enzymes ENZYME proteins Transferases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006012 [galactose metabolic process] GO:0033858 [N-acetylgalactosamine kinase activity] GO:0046835 [carbohydrate phosphorylation] Show all	447 aa 49.2 kDa	No	0
GALK2-002 ENSP00000379766 ENST00000396509	B7ZAX5 [Direct mapping] N-acetylgalactosamine kinase; cDNA, FLJ79339, highly similar to N-acetylgalactosamine kinase (EC 2.7.1.157) Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006012 [galactose metabolic process] GO:0046835 [carbohydrate phosphorylation] Show all	434 aa 47.6 kDa	No	0
GALK2-003 ENSP00000453129 ENST00000560031	Q01415 [Direct mapping] N-acetylgalactosamine kinase Show all	Enzymes ENZYME proteins Transferases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006012 [galactose metabolic process] GO:0033858 [N-acetylgalactosamine kinase activity] GO:0046835 [carbohydrate phosphorylation] Show all	458 aa 50.4 kDa	No	0
GALK2-005 ENSP00000440312 ENST00000544523	B7ZAX5 [Direct mapping] N-acetylgalactosamine kinase; cDNA, FLJ79339, highly similar to N-acetylgalactosamine kinase (EC 2.7.1.157) Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006012 [galactose metabolic process] GO:0046835 [carbohydrate phosphorylation] Show all	434 aa 47.6 kDa	No	0
GALK2-006 ENSP00000453133 ENST00000559454	B7ZAX5 [Direct mapping] N-acetylgalactosamine kinase; cDNA, FLJ79339, highly similar to N-acetylgalactosamine kinase (EC 2.7.1.157) Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006012 [galactose metabolic process] GO:0046835 [carbohydrate phosphorylation] Show all	434 aa 47.6 kDa	No	0
GALK2-015 ENSP00000454123 ENST00000558145	H0YNR7 [Direct mapping] N-acetylgalactosamine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 8.9 kDa	No	0
GALK2-016 ENSP00000452614 ENST00000560138	H0YK10 [Direct mapping] N-acetylgalactosamine kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006012 [galactose metabolic process] GO:0046835 [carbohydrate phosphorylation] Show all	209 aa 22.7 kDa	No	0
GALK2-019 ENSP00000452637 ENST00000560528	H0YK30 [Direct mapping] N-acetylgalactosamine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12 kDa	No	0
GALK2-020 ENSP00000453252 ENST00000558399	H0YLL3 [Direct mapping] N-acetylgalactosamine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 18 kDa	No	0
GALK2-021 ENSP00000453257 ENST00000559580	H0YLL8 [Direct mapping] N-acetylgalactosamine kinase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 17.9 kDa	No	0
GALK2-022 ENSP00000453961 ENST00000560654	H0YND3 [Direct mapping] N-acetylgalactosamine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004335 [galactokinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006012 [galactose metabolic process] GO:0046835 [carbohydrate phosphorylation] Show all	131 aa 14.2 kDa	No	0