Expression of HTR5A in cancer - Summary

CANCER ATLAS

Gene description

5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB017467

GENE INFORMATION
Gene name	HTR5A (HGNC Symbol)
Synonyms	5-HT5A
Description	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled (HGNC Symbol)
Entrez gene summary	The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q36.2
Chromosome location (bp)	155070324 - 155085749
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000157219 (version 83.38)
Entrez gene	3361
UniProt	P47898 (UniProt - Evidence at transcript level)
neXtProt	NX_P47898
Antibodypedia	HTR5A antibodies

PROTEIN BROWSER

HTR5A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTR5A-001 ENSP00000287907 ENST00000287907	P47898 [Direct mapping] 5-hydroxytryptamine receptor 5A A4D2N2 [Target identity:100%; Query identity:100%] 5-hydroxytryptamine (Serotonin) receptor 5A; cDNA FLJ36936 fis, clone BRACE2005395, highly similar to 5-HYDROXYTRYPTAMINE 5A RECEPTOR Show all	G-protein coupled receptors GPCRs excl olfactory receptors Serotonin receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004993 [serotonin receptor activity] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007210 [serotonin receptor signaling pathway] GO:0007420 [brain development] GO:0016021 [integral component of membrane] GO:0019933 [cAMP-mediated signaling] GO:0021766 [hippocampus development] GO:0030425 [dendrite] GO:0032355 [response to estradiol] GO:0043204 [perikaryon] Show all	357 aa 40.3 kDa	No	7