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HTR5A

GENERAL INFORMATION

Gene name

 HTR5A

Gene description

 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Tissue enhanced (cerebellum, caudate)

Protein evidence

 Evidence at transcript level

Protein expression

 General cytoplasmic expression in several different tissue types

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB017467
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, caudate)

GENE INFORMATION

Gene name

 HTR5A (HGNC Symbol)

Synonyms

 5-HT5A

Description

 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled (HGNC Symbol)

Entrez gene summary

 The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q36.2

Chromosome location (bp)

 155070324 - 155085749

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000157219 (version 83.38)

Entrez gene

 3361

UniProt

 P47898 (UniProt - Evidence at transcript level)

neXtProt

 NX_P47898

Antibodypedia

 HTR5A antibodies

PROTEIN BROWSER
HTR5A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR5A-001
ENSP00000287907
ENST00000287907
P47898 [Direct mapping]
5-hydroxytryptamine receptor 5A
A4D2N2 [Target identity:100%; Query identity:100%]
5-hydroxytryptamine (Serotonin) receptor 5A; cDNA FLJ36936 fis, clone BRACE2005395, highly similar to 5-HYDROXYTRYPTAMINE 5A RECEPTOR
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007420 [brain development]
GO:0016021 [integral component of membrane]
GO:0019933 [cAMP-mediated signaling]
GO:0021766 [hippocampus development]
GO:0030425 [dendrite]
GO:0032355 [response to estradiol]
GO:0043204 [perikaryon]
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 357 aa
40.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.