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FZD1

GENERAL INFORMATION

Gene name

 FZD1

Gene description

 Frizzled class receptor 1

Protein class

 Cancer-related genes
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB013008
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FZD1 (HGNC Symbol)

Synonyms

 DKFZp564G072

Description

 Frizzled class receptor 1 (HGNC Symbol)

Entrez gene summary

 Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.13

Chromosome location (bp)

 91264364 - 91271326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157240 (version 83.38)

Entrez gene

 8321

UniProt

 Q9UP38 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UP38

Antibodypedia

 FZD1 antibodies

PROTEIN BROWSER
FZD1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD1-001
ENSP00000287934
ENST00000287934
Q9UP38 [Direct mapping]
Frizzled-1
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003149 [membranous septum morphogenesis]
GO:0003150 [muscular septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0017147 [Wnt-protein binding]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030855 [epithelial cell differentiation]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0035425 [autocrine signaling]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042493 [response to drug]
GO:0042813 [Wnt-activated receptor activity]
GO:0043005 [neuron projection]
GO:0044338 [canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation]
GO:0044339 [canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048286 [lung alveolus development]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060022 [hard palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060412 [ventricular septum morphogenesis]
GO:0071305 [cellular response to vitamin D]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 647 aa
71.2 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.