Cell atlas - TNFRSF14 - The Human Protein Atlas

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TNFRSF14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Rods & Rings

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	TNFRSF14
Gene description	Tumor necrosis factor receptor superfamily, member 14
Protein class	Cancer-related genes CD markers Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the rods & rings.
RNA cell category	Cell line enhanced (SK-MEL-30, HDLM-2, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Rods & Rings (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006404
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, HDLM-2, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the rods & rings.

Main location

Cytosol (approved)

Additional location

Rods & Rings (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006404	A-431	Cytosol
	HPA006404	U-2 OS	Cytosol
	HPA006404	U-2 OS	Rods & Rings
	HPA006404	U-251 MG	No staining

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA006404	U-2 OS	Image	U-2 OS cells were treated with Ribavirin to induce the formation of Rods & Rings. Co-localization shows that TNFRSF14 localizes to Rods & Rings as the staining overlaps with a marker for Rods & Rings.

GENE INFORMATION
Gene name	TNFRSF14 (HGNC Symbol)
Synonyms	ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Description	Tumor necrosis factor receptor superfamily, member 14 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	2555639 - 2565382
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157873 (version 83.38)
Entrez gene	8764
UniProt	Q92956 (UniProt - Evidence at protein level)
neXtProt	NX_Q92956
Antibodypedia	TNFRSF14 antibodies

PROTEIN BROWSER

TNFRSF14-001	TNFRSF14-004	TNFRSF14-006	TNFRSF14-007	TNFRSF14-008	TNFRSF14-009	TNFRSF14-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF14-001 ENSP00000347948 ENST00000355716	Q92956 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 A0A024R052 [Target identity:100%; Query identity:100%] Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator), isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002741 [positive regulation of cytokine secretion involved in immune response] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0009897 [external side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031625 [ubiquitin protein ligase binding] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043410 [positive regulation of MAPK cascade] GO:0046642 [negative regulation of alpha-beta T cell proliferation] GO:0046718 [viral entry into host cell] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] GO:0097190 [apoptotic signaling pathway] GO:2000406 [positive regulation of T cell migration] Show all	283 aa 30.4 kDa	Yes	1
TNFRSF14-004 ENSP00000486304 ENST00000482602	A0A0D9SF52 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.8 kDa	No	0
TNFRSF14-006 ENSP00000399533 ENST00000451778	F6Q0M4 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	231 aa 24.9 kDa	Yes	1
TNFRSF14-007 ENSP00000399292 ENST00000435221	F6Q0M4 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	231 aa 24.9 kDa	Yes	1
TNFRSF14-008 ENSP00000415254 ENST00000434817	F6Q0M4 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	231 aa 24.9 kDa	Yes	1
TNFRSF14-009 ENSP00000386859 ENST00000409119	B9A034 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	193 aa 20.8 kDa	Yes	0
TNFRSF14-011 ENSP00000411854 ENST00000426449	F6UPZ7 [Direct mapping] Tumor necrosis factor receptor superfamily member 14 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	183 aa 19.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.