Cell atlas - HPD - The Human Protein Atlas

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HPD

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HPD
Gene description	4-hydroxyphenylpyruvate dioxygenase
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA038322
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038322	Hep G2	Nuclear speckles
	HPA038322	U-2 OS	Nuclear speckles
	HPA038322	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	HPD (HGNC Symbol)
Synonyms	4-HPPD, 4HPPD, GLOD3, PPD
Description	4-hydroxyphenylpyruvate dioxygenase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	121839527 - 121863596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158104 (version 83.38)
Entrez gene	3242
UniProt	P32754 (UniProt - Evidence at protein level)
neXtProt	NX_P32754
Antibodypedia	HPD antibodies

PROTEIN BROWSER

HPD-001	HPD-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPD-001 ENSP00000441677 ENST00000543163	P32754 [Direct mapping] 4-hydroxyphenylpyruvate dioxygenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003868 [4-hydroxyphenylpyruvate dioxygenase activity] GO:0005829 [cytosol] GO:0006559 [L-phenylalanine catabolic process] GO:0006572 [tyrosine catabolic process] GO:0009072 [aromatic amino acid family metabolic process] GO:0016701 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	354 aa 40.5 kDa	No	0
HPD-002 ENSP00000289004 ENST00000289004	A0A0B4J1R4 [Direct mapping] 4-hydroxyphenylpyruvate dioxygenase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003868 [4-hydroxyphenylpyruvate dioxygenase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0009072 [aromatic amino acid family metabolic process] GO:0016701 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	393 aa 45 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.