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RNA tissue category: Group enriched (liver, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GENE INFORMATION
Gene name
HPD (HGNC Symbol)
Synonyms
4-HPPD, 4HPPD, GLOD3, PPD
Description
4-hydroxyphenylpyruvate dioxygenase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003868 [4-hydroxyphenylpyruvate dioxygenase activity] GO:0005829 [cytosol] GO:0006559 [L-phenylalanine catabolic process] GO:0006572 [tyrosine catabolic process] GO:0009072 [aromatic amino acid family metabolic process] GO:0016701 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
