Expression of CNNM4 in cancer - Summary

CANCER ATLAS

Gene description

Cyclin and CBS domain divalent metal cation transport mediator 4

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA017732

GENE INFORMATION
Gene name	CNNM4 (HGNC Symbol)
Synonyms	ACDP4, KIAA1592
Description	Cyclin and CBS domain divalent metal cation transport mediator 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	96760902 - 96811891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158158 (version 83.38)
Entrez gene	26504
UniProt	Q6P4Q7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P4Q7
Antibodypedia	CNNM4 antibodies

PROTEIN BROWSER

CNNM4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNNM4-001 ENSP00000366275 ENST00000377075	Q6P4Q7 [Direct mapping] Metal transporter CNNM4 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007601 [visual perception] GO:0010960 [magnesium ion homeostasis] GO:0015081 [sodium ion transmembrane transporter activity] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0070166 [enamel mineralization] GO:1903830 [magnesium ion transmembrane transport] Show all	775 aa 86.6 kDa	Yes	4