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CNNM4

GENERAL INFORMATION

Gene name

 CNNM4

Gene description

 Cyclin and CBS domain divalent metal cation transport mediator 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Nuclear staining in testis is viewed as off target and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA017732
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CNNM4 (HGNC Symbol)

Synonyms

 ACDP4, KIAA1592

Description

 Cyclin and CBS domain divalent metal cation transport mediator 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 96760902 - 96811891

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158158 (version 83.38)

Entrez gene

 26504

UniProt

 Q6P4Q7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P4Q7

Antibodypedia

 CNNM4 antibodies

PROTEIN BROWSER
CNNM4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNNM4-001
ENSP00000366275
ENST00000377075
Q6P4Q7 [Direct mapping]
Metal transporter CNNM4
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Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007601 [visual perception]
GO:0010960 [magnesium ion homeostasis]
GO:0015081 [sodium ion transmembrane transporter activity]
GO:0015095 [magnesium ion transmembrane transporter activity]
GO:0015693 [magnesium ion transport]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0070166 [enamel mineralization]
GO:1903830 [magnesium ion transmembrane transport]
Show all
 775 aa
86.6 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.