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Several cases of breasts, renal, stomach and ovarian cancers showed weak membranous and cytoplasmic staining. Colorectal and testis cancers exhibited weak membranous positivity while few cases of pancreatic cancers showed moderate staining. Several cases of melanoma displayed weak cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KCNB1 (HGNC Symbol)
Synonyms
Kv2.1
Description
Potassium channel, voltage gated Shab related subfamily B, member 1 (HGNC Symbol)
Entrez gene summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]