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KCNB1

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GENERAL INFORMATION

Gene name

 KCNB1

Gene description

 Potassium channel, voltage gated Shab related subfamily B, member 1

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-2 OS, SK-BR-3, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, SK-BR-3, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 KCNB1 (HGNC Symbol)

Synonyms

 Kv2.1

Description

 Potassium channel, voltage gated Shab related subfamily B, member 1 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 49363877 - 49484297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158445 (version 83.38)

Entrez gene

 3745

UniProt

 Q14721 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14721

Antibodypedia

 KCNB1 antibodies

PROTEIN BROWSER
KCNB1-001
KCNB1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNB1-001
ENSP00000360806
ENST00000371741
Q14721 [Direct mapping]
Potassium voltage-gated channel subfamily B member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016328 [lateral plasma membrane]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031669 [cellular response to nutrient levels]
GO:0032182 [ubiquitin-like protein binding]
GO:0032809 [neuronal cell body membrane]
GO:0033605 [positive regulation of catecholamine secretion]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042593 [glucose homeostasis]
GO:0043204 [perikaryon]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0046676 [negative regulation of insulin secretion]
GO:0046982 [protein heterodimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071333 [cellular response to glucose stimulus]
GO:0071805 [potassium ion transmembrane transport]
GO:0072661 [protein targeting to plasma membrane]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0098900 [regulation of action potential]
GO:1900454 [positive regulation of long term synaptic depression]
GO:2000671 [regulation of motor neuron apoptotic process]
Show all
 858 aa
95.9 kDa 		No 6
KCNB1-002
ENSP00000489193
ENST00000635465
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
Show all
 858 aa
95.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.