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Cancer tissues showed moderate nuclear membranous and cytoplasmic staining. Several cases of gliomas, lymphomas, colorectal, ovarian, cervix, endometrial and testis cancers along with occasional cases of melanomas and urothelial cancers showed strong positivity.
Cancer cells showed moderate cytoplasmic and nuclear immunoreactivity. Several cases of gliomas were strongly stained.
GENE INFORMATION
Gene name
ZFAND2B (HGNC Symbol)
Synonyms
AIRAPL
Description
Zinc finger, AN1-type domain 2B (HGNC Symbol)
Entrez gene summary
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]