Cell atlas - ZFAND2B - The Human Protein Atlas

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ZFAND2B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZFAND2B
Gene description	Zinc finger, AN1-type domain 2B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035160
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035160	A-431	Nucleus
			Nucleoli
			Cytosol
	HPA035160	U-2 OS	Nucleus
	HPA035160	U-2 OS	Nucleoli
	HPA035160	U-251 MG	Nucleus
	HPA035160	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	ZFAND2B (HGNC Symbol)
Synonyms	AIRAPL
Description	Zinc finger, AN1-type domain 2B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219195237 - 219209651
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158552 (version 83.38)
Entrez gene	130617
UniProt	Q8WV99 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV99
Antibodypedia	ZFAND2B antibodies

PROTEIN BROWSER

ZFAND2B-001	ZFAND2B-002	ZFAND2B-003	ZFAND2B-004	ZFAND2B-006	ZFAND2B-008	ZFAND2B-009	ZFAND2B-011	ZFAND2B-013	ZFAND2B-017	ZFAND2B-019	ZFAND2B-201	ZFAND2B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZFAND2B-001 ENSP00000289528 ENST00000289528	Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B A0A024R435 [Target identity:100%; Query identity:100%] Zinc finger, AN1-type domain 2B, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270 [zinc ion binding] Show all	257 aa 28 kDa	No	0
ZFAND2B-002 ENSP00000386399 ENST00000409594	Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270 [zinc ion binding] Show all	176 aa 19.3 kDa	No	0
ZFAND2B-003 ENSP00000386824 ENST00000409206	Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270 [zinc ion binding] Show all	176 aa 19.3 kDa	No	0
ZFAND2B-004 ENSP00000387179 ENST00000409097	B4DEN4 [Direct mapping] AN1-type zinc finger protein 2B; cDNA FLJ60439, highly similar to AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	225 aa 24.6 kDa	No	0
ZFAND2B-006 ENSP00000409931 ENST00000422255	E7EV05 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	214 aa 23.4 kDa	No	0
ZFAND2B-008 ENSP00000386847 ENST00000409412	B8ZZ56 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	145 aa 16.2 kDa	No	0
ZFAND2B-009 ENSP00000386898 ENST00000409336	Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B A0A024R435 [Target identity:100%; Query identity:100%] Zinc finger, AN1-type domain 2B, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270 [zinc ion binding] Show all	257 aa 28 kDa	No	0
ZFAND2B-011 ENSP00000386370 ENST00000409217	E9PFU9 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	224 aa 24.6 kDa	No	0
ZFAND2B-013 ENSP00000387312 ENST00000409319	B8ZZ56 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	145 aa 16.2 kDa	No	0
ZFAND2B-017 ENSP00000416138 ENST00000425849	H7C491 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 15.9 kDa	No	0
ZFAND2B-019 ENSP00000400760 ENST00000436556	C9J1R6 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	50 aa 5.5 kDa	No	0
ZFAND2B-201 ENSP00000411334 ENST00000444522	Q8WV99 [Direct mapping] AN1-type zinc finger protein 2B A0A024R435 [Target identity:100%; Query identity:100%] Zinc finger, AN1-type domain 2B, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006616 [SRP-dependent cotranslational protein targeting to membrane, translocation] GO:0008270 [zinc ion binding] Show all	257 aa 28 kDa	No	0
ZFAND2B-202 ENSP00000483320 ENST00000621130	A0A087X0D9 [Direct mapping] AN1-type zinc finger protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	213 aa 23.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.