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Weak cytoplasmic immunoreactivity was observed in most malignant cells. A majority of squamous cell carcinomas, renal and gastric cancers were negative.
GENE INFORMATION
Gene name
ADAMTS4 (HGNC Symbol)
Synonyms
ADAMTS-2, ADMP-1, KIAA0688
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
