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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAMTS4
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 4

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB025876

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak cytoplasmic immunoreactivity was observed in most malignant cells. A majority of squamous cell carcinomas, renal and gastric cancers were negative.

GENE INFORMATION

Gene name

ADAMTS4 (HGNC Symbol)

Synonyms

ADAMTS-2, ADMP-1, KIAA0688

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161184308 - 161199056

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158859 (version 83.38)

Entrez gene

9507

UniProt

O75173 (UniProt - Evidence at protein level)

neXtProt

NX_O75173

Antibodypedia

ADAMTS4 antibodies

PROTEIN BROWSER

ADAMTS4-001
ADAMTS4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS4-001
ENSP00000356975
ENST00000367996
O75173 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0002020 [protease binding]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0042742 [defense response to bacterium]
Show all
837 aa
90.2 kDa
No 0
ADAMTS4-002
ENSP00000356974
ENST00000367995
Q5VTW1 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 4
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
339 aa
36 kDa
No 0

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