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Few cases of cervix, colorectal, liver, ovarian, pancreas, stomach and urothelial cancers showed weak to moderate dot like cytoplasmic staining. Few cases of endometrial cancers showed moderate to strong positivity. Several cases of prostate cancers showed weak to moderate nuclear immunoreactivity. Remaining cancer tissues were negative.
Prostate cancers showed moderate nuclear positivity. Rarely melanoma showed strong cytoplasmic immunoreactivity. Few cases of ovarian cancers displayed moderate cytoplasmic staining. Remaining cancer tissues were in general weakly stained or negative.
Prostate cancer showed moderate to strong nuclear immunoreactivity. Other malignancies were negative.
GENE INFORMATION
Gene name
HOXB13
Synonyms
Description
Homeobox B13 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
