Expression of CLIC6 in cancer - Summary

CANCER ATLAS

Gene description

Chloride intracellular channel 6

Protein class

Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA055123	HPA065285

GENE INFORMATION
Gene name	CLIC6 (HGNC Symbol)
Synonyms	CLIC1L, CLIC5
Description	Chloride intracellular channel 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
Chromosome	21
Cytoband	q22.12
Chromosome location (bp)	34669389 - 34718227
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159212 (version 83.38)
Entrez gene	54102
UniProt	Q96NY7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96NY7
Antibodypedia	CLIC6 antibodies

PROTEIN BROWSER

CLIC6-001	CLIC6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLIC6-001 ENSP00000353959 ENST00000360731	Q96NY7 [Direct mapping] Chloride intracellular channel protein 6 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0034707 [chloride channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0050780 [dopamine receptor binding] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] Show all	704 aa 73 kDa	No	0
CLIC6-002 ENSP00000290332 ENST00000349499	Q96NY7 [Direct mapping] Chloride intracellular channel protein 6 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0034707 [chloride channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0050780 [dopamine receptor binding] GO:0070062 [extracellular exosome] GO:1902476 [chloride transmembrane transport] Show all	686 aa 71 kDa	No	0