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CLIC6

GENERAL INFORMATION

Gene name

 CLIC6

Gene description

 Chloride intracellular channel 6

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach)
GTEx:Tissue enhanced (stomach)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA055123 , HPA065285
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 CLIC6 (HGNC Symbol)

Synonyms

 CLIC1L, CLIC5

Description

 Chloride intracellular channel 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

Chromosome

 21

Cytoband

 q22.12

Chromosome location (bp)

 34669389 - 34718227

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159212 (version 83.38)

Entrez gene

 54102

UniProt

 Q96NY7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96NY7

Antibodypedia

 CLIC6 antibodies

PROTEIN BROWSER
CLIC6-001
CLIC6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIC6-001
ENSP00000353959
ENST00000360731
Q96NY7 [Direct mapping]
Chloride intracellular channel protein 6
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050780 [dopamine receptor binding]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
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 704 aa
73 kDa 		No 0
CLIC6-002
ENSP00000290332
ENST00000349499
Q96NY7 [Direct mapping]
Chloride intracellular channel protein 6
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0034707 [chloride channel complex]
GO:0034765 [regulation of ion transmembrane transport]
GO:0050780 [dopamine receptor binding]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
Show all
 686 aa
71 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.