Expression of IGF2BP1 in cancer - Summary

CANCER ATLAS

Gene description

Insulin-like growth factor 2 mRNA binding protein 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA021367	HPA062273

GENE INFORMATION
Gene name	IGF2BP1 (HGNC Symbol)
Synonyms	IMP-1
Description	Insulin-like growth factor 2 mRNA binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48997412 - 49055650
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159217 (version 83.38)
Entrez gene	10642
UniProt	Q9NZI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZI8
Antibodypedia	IGF2BP1 antibodies

PROTEIN BROWSER

IGF2BP1-001	IGF2BP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGF2BP1-001 ENSP00000290341 ENST00000290341	Q9NZI8 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006403 [RNA localization] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0010610 [regulation of mRNA stability involved in response to stress] GO:0017148 [negative regulation of translation] GO:0022013 [pallium cell proliferation in forebrain] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030529 [ribonucleoprotein complex] GO:0042035 [regulation of cytokine biosynthetic process] GO:0043197 [dendritic spine] GO:0044822 [poly(A) RNA binding] GO:0045182 [translation regulator activity] GO:0048027 [mRNA 5'-UTR binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] GO:0070934 [CRD-mediated mRNA stabilization] GO:0070937 [CRD-mediated mRNA stability complex] GO:0097150 [neuronal stem cell population maintenance] Show all	577 aa 63.5 kDa	No	0
IGF2BP1-002 ENSP00000389135 ENST00000431824	Q9NZI8 [Direct mapping] Insulin-like growth factor 2 mRNA-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003730 [mRNA 3'-UTR binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0010494 [cytoplasmic stress granule] GO:0010610 [regulation of mRNA stability involved in response to stress] GO:0017148 [negative regulation of translation] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030529 [ribonucleoprotein complex] GO:0042035 [regulation of cytokine biosynthetic process] GO:0043197 [dendritic spine] GO:0044822 [poly(A) RNA binding] GO:0045182 [translation regulator activity] GO:0048027 [mRNA 5'-UTR binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051028 [mRNA transport] GO:0070934 [CRD-mediated mRNA stabilization] GO:0070937 [CRD-mediated mRNA stability complex] Show all	438 aa 48.6 kDa	No	0