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IGF2BP1

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GENERAL INFORMATION

Gene name

 IGF2BP1

Gene description

 Insulin-like growth factor 2 mRNA binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol.

RNA cell category

 Cell line enhanced (CACO-2, AF22, REH)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA021367
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, AF22, REH)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021367 CACO-2 Cytosol
HPA021367 Hep G2 Cytosol
HPA021367 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 IGF2BP1 (HGNC Symbol)

Synonyms

 IMP-1

Description

 Insulin-like growth factor 2 mRNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48997412 - 49055650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159217 (version 83.38)

Entrez gene

 10642

UniProt

 Q9NZI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZI8

Antibodypedia

 IGF2BP1 antibodies

PROTEIN BROWSER
IGF2BP1-001
IGF2BP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGF2BP1-001
ENSP00000290341
ENST00000290341
Q9NZI8 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006403 [RNA localization]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010610 [regulation of mRNA stability involved in response to stress]
GO:0017148 [negative regulation of translation]
GO:0022013 [pallium cell proliferation in forebrain]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030529 [ribonucleoprotein complex]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0043197 [dendritic spine]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
GO:0097150 [neuronal stem cell population maintenance]
Show all
 577 aa
63.5 kDa 		No 0
IGF2BP1-002
ENSP00000389135
ENST00000431824
Q9NZI8 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010610 [regulation of mRNA stability involved in response to stress]
GO:0017148 [negative regulation of translation]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030529 [ribonucleoprotein complex]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0043197 [dendritic spine]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051028 [mRNA transport]
GO:0070934 [CRD-mediated mRNA stabilization]
GO:0070937 [CRD-mediated mRNA stability complex]
Show all
 438 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.