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Several cases of melanomas and a few cases of endometrial cancers displayed moderate to strong cytoplasmic immunoreactivity. A few cases of breast, prostate and ovarian cancers showed weak to moderate cytoplasmic and nuclear staining. The remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
GJD2 (HGNC Symbol)
Synonyms
CX36, GJA9
Description
Gap junction protein, delta 2, 36kDa (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion. [provided by RefSeq, Oct 2012]
