Expression of SIM2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Single-minded family bHLH transcription factor 2

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029295

GENE INFORMATION
Gene name	SIM2 (HGNC Symbol)
Synonyms	bHLHe15, MGC119447, SIM
Description	Single-minded family bHLH transcription factor 2 (HGNC Symbol)
Entrez gene summary	This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Chromosome	21
Cytoband	q22.13
Chromosome location (bp)	36699133 - 36749917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159263 (version 83.38)
Entrez gene	6493
UniProt	Q14190 (UniProt - Evidence at protein level)
neXtProt	NX_Q14190
Antibodypedia	SIM2 antibodies

PROTEIN BROWSER

SIM2-001	SIM2-004	SIM2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIM2-001 ENSP00000290399 ENST00000290399	Q14190 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0009880 [embryonic pattern specification] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	667 aa 73.2 kDa	No	0
SIM2-004 ENSP00000392003 ENST00000431229	H7BZX8 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	480 aa 53.7 kDa	No	0
SIM2-005 ENSP00000476273 ENST00000483178	V9GY04 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	73 aa 8.3 kDa	No	0