Cell atlas - SIM2 - The Human Protein Atlas

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SIM2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SIM2
Gene description	Single-minded family bHLH transcription factor 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies & nucleoplasm.
RNA cell category	Cell line enhanced (RPTEC TERT1, PC-3, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Nuclear bodies (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029295
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, PC-3, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies & nucleoplasm.

Main location

Nucleoplasm (supported), Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029295	A-431	Nucleoplasm
	HPA029295	A-431	Nuclear bodies	Intensity
	HPA029295	U-2 OS	Nucleoplasm
	HPA029295	U-2 OS	Nuclear bodies	Intensity
	HPA029295	U-251 MG	Nucleoplasm
	HPA029295	U-251 MG	Nuclear bodies	Intensity

GENE INFORMATION
Gene name	SIM2 (HGNC Symbol)
Synonyms	bHLHe15, MGC119447, SIM
Description	Single-minded family bHLH transcription factor 2 (HGNC Symbol)
Entrez gene summary	This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Chromosome	21
Cytoband	q22.13
Chromosome location (bp)	36699133 - 36749917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159263 (version 83.38)
Entrez gene	6493
UniProt	Q14190 (UniProt - Evidence at protein level)
neXtProt	NX_Q14190
Antibodypedia	SIM2 antibodies

PROTEIN BROWSER

SIM2-001	SIM2-004	SIM2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIM2-001 ENSP00000290399 ENST00000290399	Q14190 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0009880 [embryonic pattern specification] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] Show all	667 aa 73.2 kDa	No	0
SIM2-004 ENSP00000392003 ENST00000431229	H7BZX8 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	480 aa 53.7 kDa	No	0
SIM2-005 ENSP00000476273 ENST00000483178	V9GY04 [Direct mapping] Single-minded homolog 2 Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	73 aa 8.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.