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Most of the tumour tissues displayed weak to moderate cytoplasmic positivity. Renal and prostate cancers along with several cases of ovarian, skin and gastric cancers were negative.
Most tumour cells showed moderate cytoplasmic positivity. Most cervical cancers were weakly stained or negative. Several melanomas, hepatocellular and urothelial cancers displayed strong staining.
GENE INFORMATION
Gene name
AMFR (HGNC Symbol)
Synonyms
gp78, RNF45
Description
Autocrine motility factor receptor, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]