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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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AMFR
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AMFR

Gene description

Autocrine motility factor receptor, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and membrane expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA029018 , CAB026381
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

AMFR (HGNC Symbol)

Synonyms

gp78, RNF45

Description

Autocrine motility factor receptor, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

Chromosome

16

Cytoband

q13

Chromosome location (bp)

56361452 - 56425538

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159461 (version 83.38)

Entrez gene

267

UniProt

Q9UKV5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKV5

Antibodypedia

AMFR antibodies

PROTEIN BROWSER

AMFR-001
AMFR-002
AMFR-005
AMFR-007
AMFR-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AMFR-001
ENSP00000290649
ENST00000290649
Q9UKV5 [Direct mapping]
E3 ubiquitin-protein ligase AMFR
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007165 [signal transduction]
GO:0007568 [aging]
GO:0007611 [learning or memory]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016874 [ligase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030674 [protein binding, bridging]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032092 [positive regulation of protein binding]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051087 [chaperone binding]
GO:0051259 [protein oligomerization]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1904288 [BAT3 complex binding]
GO:1990381 [ubiquitin-specific protease binding]
Show all
643 aa
73 kDa
Yes 6
AMFR-002
ENSP00000473636
ENST00000492830
R4GNG2 [Direct mapping]
E3 ubiquitin-protein ligase AMFR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
299 aa
33.9 kDa
No 0
AMFR-005
ENSP00000456745
ENST00000565445
H3BSK3 [Direct mapping]
E3 ubiquitin-protein ligase AMFR
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
229 aa
26.8 kDa
No 7
AMFR-007
ENSP00000455842
ENST00000563664
H3BQM3 [Direct mapping]
E3 ubiquitin-protein ligase AMFR
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
165 aa
19 kDa
No 4
AMFR-009
ENSP00000456288
ENST00000567738
H3BRK9 [Direct mapping]
E3 ubiquitin-protein ligase AMFR
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
288 aa
32.8 kDa
No 0

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The Human Protein Atlas project is funded
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