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Prostate cancers displayed moderate to strong cytoplasmic and membranous positivity. A few cases of carcinoids and melanomas showed moderate cytoplasmic positivity. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
SPON2 (HGNC Symbol)
Synonyms
DIL1
Description
Spondin 2, extracellular matrix protein (HGNC Symbol)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001530 [lipopolysaccharide binding] GO:0002448 [mast cell mediated immunity] GO:0003823 [antigen binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0008228 [opsonization] GO:0032496 [response to lipopolysaccharide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0042742 [defense response to bacterium] GO:0043152 [induction of bacterial agglutination] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] GO:0051607 [defense response to virus] GO:0060907 [positive regulation of macrophage cytokine production] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide]