Cell atlas - SPON2 - The Human Protein Atlas

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SPON2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SPON2
Gene description	Spondin 2, extracellular matrix protein
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (ASC TERT1, HaCaT, U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066095
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, HaCaT, U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066095	HaCaT	Vesicles	Intensity
	HPA066095	Hep G2	No staining

GENE INFORMATION
Gene name	SPON2 (HGNC Symbol)
Synonyms	DIL1
Description	Spondin 2, extracellular matrix protein (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1166932 - 1208962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159674 (version 83.38)
Entrez gene	10417
UniProt	Q9BUD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUD6
Antibodypedia	SPON2 antibodies

PROTEIN BROWSER

SPON2-001	SPON2-002	SPON2-006	SPON2-009	SPON2-012	SPON2-013	SPON2-014	SPON2-015	SPON2-201	SPON2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPON2-001 ENSP00000290902 ENST00000290902	Q9BUD6 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	331 aa 35.8 kDa	Yes	0
SPON2-002 ENSP00000424542 ENST00000503765	D6RB12 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		108 aa 11.7 kDa	Yes	0
SPON2-006 ENSP00000421634 ENST00000514490	D6REX2 [Direct mapping] Spondin-2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.3 kDa	No	0
SPON2-009 ENSP00000423414 ENST00000511679	D6RA41 [Direct mapping] Spondin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.5 kDa	No	0
SPON2-012 ENSP00000421379 ENST00000509233	D6RFY9 [Direct mapping] Spondin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.7 kDa	No	0
SPON2-013 ENSP00000421858 ENST00000511672		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.8 kDa	No	0
SPON2-014 ENSP00000422516 ENST00000502483	D6RBY3 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.2 kDa	Yes	0
SPON2-015 ENSP00000425871 ENST00000515004	D6RIH5 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 6.7 kDa	Yes	0
SPON2-201 ENSP00000394832 ENST00000431380	Q9BUD6 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	331 aa 35.8 kDa	Yes	0
SPON2-202 ENSP00000483599 ENST00000617421	Q9BUD6 [Direct mapping] Spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001530 [lipopolysaccharide binding] GO:0002448 [mast cell mediated immunity] GO:0003823 [antigen binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0008228 [opsonization] GO:0032496 [response to lipopolysaccharide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0042742 [defense response to bacterium] GO:0043152 [induction of bacterial agglutination] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0050832 [defense response to fungus] GO:0051607 [defense response to virus] GO:0060907 [positive regulation of macrophage cytokine production] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide] Show all	331 aa 35.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.