Expression of FNDC5 in cancer - Summary - The Human Protein Atlas

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FNDC5

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Fibronectin type III domain containing 5

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA051290

GENE INFORMATION
Gene name	FNDC5 (HGNC Symbol)
Synonyms	FRCP2
Description	Fibronectin type III domain containing 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Chromosome	1
Cytoband	p35.1
Chromosome location (bp)	32862268 - 32872482
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160097 (version 83.38)
Entrez gene	252995
UniProt	Q8NAU1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NAU1
Antibodypedia	FNDC5 antibodies

PROTEIN BROWSER

FNDC5-001	FNDC5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FNDC5-001 ENSP00000362570 ENST00000373471	A0A0A0MRR6 [Direct mapping] Fibronectin type III domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0014850 [response to muscle activity] GO:0016021 [integral component of membrane] GO:0090336 [positive regulation of brown fat cell differentiation] Show all	212 aa 23.6 kDa	Yes	1
FNDC5-006 ENSP00000476320 ENST00000496770	Q8NAU1 [Direct mapping] Fibronectin type III domain-containing protein 5 Irisin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005778 [peroxisomal membrane] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0008150 [biological_process] GO:0014850 [response to muscle activity] GO:0016021 [integral component of membrane] GO:0090336 [positive regulation of brown fat cell differentiation] Show all	153 aa 17.3 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.