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FNDC5

GENERAL INFORMATION

Gene name

 FNDC5

Gene description

 Fibronectin type III domain containing 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Tissue enhanced (cerebellum, skeletal muscle)
FANTOM5:Tissue enhanced (cerebellum, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including heart and skeletal muscle cells.

DATA RELIABILITY

Data reliability
description

 Pending retesting.

Reliability score

 Approved based on 1 antibody.
HPA051290
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, skeletal muscle)

GENE INFORMATION

Gene name

 FNDC5 (HGNC Symbol)

Synonyms

 FRCP2

Description

 Fibronectin type III domain containing 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

 1

Cytoband

 p35.1

Chromosome location (bp)

 32862268 - 32872482

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160097 (version 83.38)

Entrez gene

 252995

UniProt

 Q8NAU1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NAU1

Antibodypedia

 FNDC5 antibodies

PROTEIN BROWSER
FNDC5-001
FNDC5-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FNDC5-001
ENSP00000362570
ENST00000373471
A0A0A0MRR6 [Direct mapping]
Fibronectin type III domain-containing protein 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0014850 [response to muscle activity]
GO:0016021 [integral component of membrane]
GO:0090336 [positive regulation of brown fat cell differentiation]
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 212 aa
23.6 kDa 		Yes 1
FNDC5-006
ENSP00000476320
ENST00000496770
Q8NAU1 [Direct mapping]
Fibronectin type III domain-containing protein 5 Irisin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0008150 [biological_process]
GO:0014850 [response to muscle activity]
GO:0016021 [integral component of membrane]
GO:0090336 [positive regulation of brown fat cell differentiation]
Show all
 153 aa
17.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.