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Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007586 [digestion] GO:0008284 [positive regulation of cell proliferation] GO:0019722 [calcium-mediated signaling] GO:0030334 [regulation of cell migration] GO:0031723 [CXCR4 chemokine receptor binding] GO:0043031 [negative regulation of macrophage activation] GO:0050728 [negative regulation of inflammatory response] GO:0060455 [negative regulation of gastric acid secretion] GO:0070062 [extracellular exosome] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
