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TFF1

GENERAL INFORMATION

Gene name

 TFF1

Gene description

 Trefoil factor 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (stomach)
GTEx:Tissue enriched (stomach)
FANTOM5:Tissue enriched (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in the superficial layer of gastric mucosa and goblet cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003425 , CAB002170
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (gallbladder)

GENE INFORMATION

Gene name

 TFF1 (HGNC Symbol)

Synonyms

 BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2

Description

 Trefoil factor 1 (HGNC Symbol)

Entrez gene summary

 Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 42362282 - 42366594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160182 (version 83.38)

Entrez gene

 7031

UniProt

 P04155 (UniProt - Evidence at protein level)

neXtProt

 NX_P04155

Antibodypedia

 TFF1 antibodies

PROTEIN BROWSER
TFF1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFF1-001
ENSP00000291527
ENST00000291527
P04155 [Direct mapping]
Trefoil factor 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005975 [carbohydrate metabolic process]
GO:0007586 [digestion]
GO:0008083 [growth factor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0010039 [response to iron ion]
GO:0030154 [cell differentiation]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0035902 [response to immobilization stress]
GO:0043434 [response to peptide hormone]
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 84 aa
9.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.