Cell atlas - WDR4 - The Human Protein Atlas

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WDR4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	WDR4
Gene description	WD repeat domain 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA017381
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017381	A-431	Nucleus
	HPA017381	A-431	Cytosol
	HPA017381	U-2 OS	Nucleus
	HPA017381	U-2 OS	Cytosol
	HPA017381	U-251 MG	Nucleoplasm
	HPA017381	U-251 MG	Cytosol

GENE INFORMATION
Gene name	WDR4 (HGNC Symbol)
Synonyms	TRM82, TRMT82
Description	WD repeat domain 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	42843094 - 42879568
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160193 (version 83.38)
Entrez gene	10785
UniProt	P57081 (UniProt - Evidence at protein level)
neXtProt	NX_P57081
Antibodypedia	WDR4 antibodies

PROTEIN BROWSER

WDR4-001	WDR4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR4-001 ENSP00000381266 ENST00000398208	P57081 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] Show all	412 aa 45.5 kDa	No	0
WDR4-004 ENSP00000328671 ENST00000330317	P57081 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] Show all	412 aa 45.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.