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FTCD

CANCER ATLAS

Gene description

 Formimidoyltransferase cyclodeaminase

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020073
HPA030928
HPA030929
HPA036114

GENE INFORMATION

Gene name

 FTCD

Synonyms

Description

 Formimidoyltransferase cyclodeaminase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 46136262 - 46155567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160282 (version 83.38)

Entrez gene

 10841

UniProt

 O95954 (UniProt - Evidence at protein level)

neXtProt

 NX_O95954

Antibodypedia

 FTCD antibodies

PROTEIN BROWSER
FTCD-001
FTCD-002
FTCD-004
FTCD-005
FTCD-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FTCD-001
ENSP00000380854
ENST00000397746
O95954 [Direct mapping]
Formimidoyltransferase-cyclodeaminase Glutamate formimidoyltransferase Formimidoyltetrahydrofolate cyclodeaminase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Lyases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005542 [folic acid binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0019556 [histidine catabolic process to glutamate and formamide]
GO:0019557 [histidine catabolic process to glutamate and formate]
GO:0030407 [formimidoyltransferase activity]
GO:0030409 [glutamate formimidoyltransferase activity]
GO:0030412 [formimidoyltetrahydrofolate cyclodeaminase activity]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 541 aa
58.9 kDa 		No 0
FTCD-002
ENSP00000380851
ENST00000397743
B7WPK3 [Direct mapping]
Formimidoyltransferase-cyclodeaminase
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005542 [folic acid binding]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0044237 [cellular metabolic process]
Show all
 495 aa
52.8 kDa 		No 0
FTCD-004
ENSP00000291670
ENST00000291670
O95954 [Direct mapping]
Formimidoyltransferase-cyclodeaminase Glutamate formimidoyltransferase Formimidoyltetrahydrofolate cyclodeaminase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Lyases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005542 [folic acid binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0007010 [cytoskeleton organization]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0019556 [histidine catabolic process to glutamate and formamide]
GO:0019557 [histidine catabolic process to glutamate and formate]
GO:0030407 [formimidoyltransferase activity]
GO:0030409 [glutamate formimidoyltransferase activity]
GO:0030412 [formimidoyltetrahydrofolate cyclodeaminase activity]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 541 aa
58.9 kDa 		No 0
FTCD-005
ENSP00000380856
ENST00000397748
O95954 [Direct mapping]
Formimidoyltransferase-cyclodeaminase Glutamate formimidoyltransferase Formimidoyltetrahydrofolate cyclodeaminase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Lyases
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005542 [folic acid binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006548 [histidine catabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0019556 [histidine catabolic process to glutamate and formamide]
GO:0019557 [histidine catabolic process to glutamate and formate]
GO:0030407 [formimidoyltransferase activity]
GO:0030409 [glutamate formimidoyltransferase activity]
GO:0030412 [formimidoyltetrahydrofolate cyclodeaminase activity]
GO:0030868 [smooth endoplasmic reticulum membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035999 [tetrahydrofolate interconversion]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 572 aa
61.3 kDa 		No 0
FTCD-011
ENSP00000409015
ENST00000446405
H7C315 [Direct mapping]
Formimidoyltransferase-cyclodeaminase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0044237 [cellular metabolic process]
Show all
 133 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.