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PCNT

GENERAL INFORMATION

Gene name

 PCNT

Gene description

 Pericentrin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA016820 , HPA019887
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 PCNT (HGNC Symbol)

Synonyms

 KEN, KIAA0402, PCN, PCNT2, PCNTB, SCKL4

Description

 Pericentrin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 46324122 - 46445769

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160299 (version 83.38)

Entrez gene

 5116

UniProt

 O95613 (UniProt - Evidence at protein level)

neXtProt

 NX_O95613

Antibodypedia

 PCNT antibodies

PROTEIN BROWSER
PCNT-001
PCNT-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCNT-001
ENSP00000352572
ENST00000359568
O95613 [Direct mapping]
Pericentrin
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000242 [pericentriolar material]
GO:0000278 [mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007051 [spindle organization]
GO:0016020 [membrane]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021772 [olfactory bulb development]
GO:0031514 [motile cilium]
GO:0034451 [centriolar satellite]
GO:0035108 [limb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0043066 [negative regulation of apoptotic process]
GO:0045171 [intercellular bridge]
GO:0048854 [brain morphogenesis]
GO:0061351 [neural precursor cell proliferation]
GO:0090316 [positive regulation of intracellular protein transport]
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 3336 aa
378 kDa 		No 0
PCNT-007
ENSP00000404708
ENST00000418394
H7C2A3 [Direct mapping]
Pericentrin
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 228 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.