Expression of SLC2A6 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 2 (facilitated glucose transporter), member 6

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042272	CAB046014

GENE INFORMATION
Gene name	SLC2A6 (HGNC Symbol)
Synonyms	GLUT6, GLUT9, HSA011372
Description	Solute carrier family 2 (facilitated glucose transporter), member 6 (HGNC Symbol)
Entrez gene summary	Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133471095 - 133479137
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160326 (version 83.38)
Entrez gene	11182
UniProt	Q9UGQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGQ3
Antibodypedia	SLC2A6 antibodies

PROTEIN BROWSER

SLC2A6-001	SLC2A6-002	SLC2A6-004	SLC2A6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A6-001 ENSP00000360966 ENST00000371899	Q9UGQ3 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	507 aa 54.5 kDa	No	>9
SLC2A6-002 ENSP00000360964 ENST00000371897	Q9UGQ3 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	445 aa 48 kDa	No	>9
SLC2A6-004 ENSP00000405124 ENST00000432868	F2Z2F6 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	219 aa 22.7 kDa	No	4
SLC2A6-006 ENSP00000398004 ENST00000414172	F2Z3K7 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	146 aa 15.4 kDa	No	2