Expression of CD3G in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

CD3g molecule, gamma (CD3-TCR complex)

Protein class

CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038494	CAB017520

GENE INFORMATION
Gene name	CD3G
Synonyms
Description	CD3g molecule, gamma (CD3-TCR complex) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118344344 - 118355161
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160654 (version 83.38)
Entrez gene	917
UniProt	P09693 (UniProt - Evidence at protein level)
neXtProt	NX_P09693
Antibodypedia	CD3G antibodies

PROTEIN BROWSER

CD3G-001	CD3G-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD3G-001 ENSP00000431445 ENST00000532917	P09693 [Direct mapping] T-cell surface glycoprotein CD3 gamma chain B0YIY5 [Target identity:100%; Query identity:100%] CD3g antigen, gamma polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 gamma chain; cDNA, FLJ94613, Homo sapiens CD3G antigen, gamma polypeptide (TiT3 complex) (CD3G),mRNA Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0007163 [establishment or maintenance of cell polarity] GO:0007166 [cell surface receptor signaling pathway] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030159 [receptor signaling complex scaffold activity] GO:0031295 [T cell costimulation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042101 [T cell receptor complex] GO:0042105 [alpha-beta T cell receptor complex] GO:0042110 [T cell activation] GO:0042608 [T cell receptor binding] GO:0045087 [innate immune response] GO:0046982 [protein heterodimerization activity] GO:0050776 [regulation of immune response] GO:0050852 [T cell receptor signaling pathway] GO:0070228 [regulation of lymphocyte apoptotic process] Show all	182 aa 20.5 kDa	Yes	1
CD3G-201 ENSP00000376621 ENST00000392883	A8MUH3 [Direct mapping] T-cell surface glycoprotein CD3 gamma chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] Show all	78 aa 9.2 kDa	No	0