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CD3G

GENERAL INFORMATION

Gene name

 CD3G

Gene description

 CD3g molecule, gamma (CD3-TCR complex)

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Tissue enhanced (spleen, small intestine)
FANTOM5:Tissue enhanced (tonsil, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA038494 , CAB017520
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil, lymph node)

GENE INFORMATION

Gene name

 CD3G

Synonyms

Description

 CD3g molecule, gamma (CD3-TCR complex) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118344344 - 118355161

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160654 (version 83.38)

Entrez gene

 917

UniProt

 P09693 (UniProt - Evidence at protein level)

neXtProt

 NX_P09693

Antibodypedia

 CD3G antibodies

PROTEIN BROWSER
CD3G-001
CD3G-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD3G-001
ENSP00000431445
ENST00000532917
P09693 [Direct mapping]
T-cell surface glycoprotein CD3 gamma chain
B0YIY5 [Target identity:100%; Query identity:100%]
CD3g antigen, gamma polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 gamma chain; cDNA, FLJ94613, Homo sapiens CD3G antigen, gamma polypeptide (TiT3 complex) (CD3G),mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0031295 [T cell costimulation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042608 [T cell receptor binding]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0050776 [regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0070228 [regulation of lymphocyte apoptotic process]
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 182 aa
20.5 kDa 		Yes 1
CD3G-201
ENSP00000376621
ENST00000392883
A8MUH3 [Direct mapping]
T-cell surface glycoprotein CD3 gamma chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
Show all
 78 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.