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SHC1

GENERAL INFORMATION

Gene name

 SHC1

Gene description

 SHC (Src homology 2 domain containing) transforming protein 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001844 , CAB005374 , CAB016305
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SHC1 (HGNC Symbol)

Synonyms

 p66, SHC, ShcA

Description

 SHC (Src homology 2 domain containing) transforming protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 154962298 - 154974395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160691 (version 83.38)

Entrez gene

 6464

UniProt

 P29353 (UniProt - Evidence at protein level)

neXtProt

 NX_P29353

Antibodypedia

 SHC1 antibodies

PROTEIN BROWSER
SHC1-001
SHC1-002
SHC1-003
SHC1-004
SHC1-005
SHC1-006
SHC1-007
SHC1-008
SHC1-009
SHC1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHC1-001
ENSP00000357430
ENST00000368445
P29353 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 583 aa
62.8 kDa 		No 0
SHC1-002
ENSP00000401303
ENST00000448116
P29353 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0001784 [phosphotyrosine binding]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0010008 [endosome membrane]
GO:0014070 [response to organic cyclic compound]
GO:0016032 [viral process]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030182 [neuron differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031100 [organ regeneration]
GO:0031175 [neuron projection development]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032403 [protein complex binding]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0035094 [response to nicotine]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042127 [regulation of cell proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050900 [leukocyte migration]
GO:0051219 [phosphoprotein binding]
GO:0051384 [response to glucocorticoid]
GO:0051721 [protein phosphatase 2A binding]
GO:0070435 [Shc-EGFR complex]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 584 aa
62.9 kDa 		No 0
SHC1-003
ENSP00000357434
ENST00000368449
X6R6D0 [Direct mapping]
SHC-transforming protein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
Show all
 354 aa
38.6 kDa 		No 0
SHC1-004
ENSP00000404908
ENST00000414115
Q5T188 [Direct mapping]
SHC-transforming protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
Show all
 200 aa
21.5 kDa 		No 0
SHC1-005
ENSP00000398864
ENST00000444179
Q5T187 [Direct mapping]
SHC-transforming protein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
Show all
 130 aa
14.5 kDa 		No 0
SHC1-006
ENSP00000357438
ENST00000368453
P29353 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 474 aa
51.7 kDa 		No 0
SHC1-007
ENSP00000357435
ENST00000368450
P29353 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 473 aa
51.6 kDa 		No 0
SHC1-008
ENSP00000398441
ENST00000412170
Q5T182 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
Show all
 200 aa
22 kDa 		No 0
SHC1-009
ENSP00000396162
ENST00000366442
Q5T181 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
Show all
 137 aa
14.8 kDa 		No 0
SHC1-010
ENSP00000396333
ENST00000444664
H0Y539 [Direct mapping]
SHC-transforming protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0008286 [insulin receptor signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030971 [receptor tyrosine kinase binding]
Show all
 297 aa
32.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.