Expression of FAM189B in cancer - Summary

CANCER ATLAS

Gene description

Family with sequence similarity 189, member B

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006659

GENE INFORMATION
Gene name	FAM189B (HGNC Symbol)
Synonyms	C1orf2, cote1
Description	Family with sequence similarity 189, member B (HGNC Symbol)
Entrez gene summary	This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155247205 - 155255483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160767 (version 83.38)
Entrez gene	10712
UniProt	P81408 (UniProt - Evidence at protein level)
neXtProt	NX_P81408
Antibodypedia	FAM189B antibodies

PROTEIN BROWSER

FAM189B-001	FAM189B-002	FAM189B-004	FAM189B-008	FAM189B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM189B-001 ENSP00000354958 ENST00000361361	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	668 aa 71.4 kDa	No	4
FAM189B-002 ENSP00000307128 ENST00000350210	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	572 aa 61.1 kDa	No	2
FAM189B-004 ENSP00000357352 ENST00000368368	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	650 aa 69.4 kDa	No	3
FAM189B-008 ENSP00000427011 ENST00000491082	D6RD59 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	325 aa 34.9 kDa	No	2
FAM189B-201 ENSP00000479323 ENST00000621094	Q96H71 [Direct mapping] C1orf2 protein; Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	242 aa 26.1 kDa	No	2