Cell atlas - FAM189B - The Human Protein Atlas

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FAM189B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM189B
Gene description	Family with sequence similarity 189, member B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA006659 , HPA050674
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA050674	A-431	Nucleoplasm
HPA050674	A-431	Plasma membrane
HPA050674	HEK 293	Nucleoplasm
HPA050674	U-2 OS	Nucleoplasm
HPA006659	A-431	Nucleoplasm
HPA006659	PC-3	No staining
HPA006659	U-2 OS	No staining

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000032657 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050674	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	FAM189B (HGNC Symbol)
Synonyms	C1orf2, cote1
Description	Family with sequence similarity 189, member B (HGNC Symbol)
Entrez gene summary	This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155247205 - 155255483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160767 (version 83.38)
Entrez gene	10712
UniProt	P81408 (UniProt - Evidence at protein level)
neXtProt	NX_P81408
Antibodypedia	FAM189B antibodies

PROTEIN BROWSER

FAM189B-001	FAM189B-002	FAM189B-004	FAM189B-008	FAM189B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM189B-001 ENSP00000354958 ENST00000361361	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	668 aa 71.4 kDa	No	4
FAM189B-002 ENSP00000307128 ENST00000350210	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	572 aa 61.1 kDa	No	2
FAM189B-004 ENSP00000357352 ENST00000368368	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	650 aa 69.4 kDa	No	3
FAM189B-008 ENSP00000427011 ENST00000491082	D6RD59 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	325 aa 34.9 kDa	No	2
FAM189B-201 ENSP00000479323 ENST00000621094	Q96H71 [Direct mapping] C1orf2 protein; Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	242 aa 26.1 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.