Expression of ALDH16A1 in cancer - Summary

CANCER ATLAS

Gene description

Aldehyde dehydrogenase 16 family, member A1

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059488

GENE INFORMATION
Gene name	ALDH16A1 (HGNC Symbol)
Synonyms	MGC10204
Description	Aldehyde dehydrogenase 16 family, member A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49453169 - 49471048
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161618 (version 83.38)
Entrez gene	126133
UniProt	Q8IZ83 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZ83
Antibodypedia	ALDH16A1 antibodies

PROTEIN BROWSER

ALDH16A1-001	ALDH16A1-002	ALDH16A1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH16A1-001 ENSP00000293350 ENST00000293350	Q8IZ83 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	802 aa 85.1 kDa	No	2
ALDH16A1-002 ENSP00000445088 ENST00000540132	F5H4B6 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	639 aa 67.2 kDa	Yes	1
ALDH16A1-003 ENSP00000410142 ENST00000455361	Q8IZ83 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	751 aa 79.9 kDa	No	2