Cell atlas - ALDH16A1 - The Human Protein Atlas

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ALDH16A1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ALDH16A1
Gene description	Aldehyde dehydrogenase 16 family, member A1
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059488
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059488	A-431	Mitochondria
	HPA059488	A549	Mitochondria
	HPA059488	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	ALDH16A1 (HGNC Symbol)
Synonyms	MGC10204
Description	Aldehyde dehydrogenase 16 family, member A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49453169 - 49471048
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161618 (version 83.38)
Entrez gene	126133
UniProt	Q8IZ83 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZ83
Antibodypedia	ALDH16A1 antibodies

PROTEIN BROWSER

ALDH16A1-001	ALDH16A1-002	ALDH16A1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH16A1-001 ENSP00000293350 ENST00000293350	Q8IZ83 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	802 aa 85.1 kDa	No	2
ALDH16A1-002 ENSP00000445088 ENST00000540132	F5H4B6 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	639 aa 67.2 kDa	Yes	1
ALDH16A1-003 ENSP00000410142 ENST00000455361	Q8IZ83 [Direct mapping] Aldehyde dehydrogenase family 16 member A1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	751 aa 79.9 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.