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DBF4B

GENERAL INFORMATION

Gene name

 DBF4B

Gene description

 DBF4 zinc finger B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enriched (testis)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA048465
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 DBF4B (HGNC Symbol)

Synonyms

 ASKL1, chifb, DRF1, FLJ13087, ZDBF1B

Description

 DBF4 zinc finger B (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 44708608 - 44752264

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161692 (version 83.38)

Entrez gene

 80174

UniProt

 Q8NFT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFT6

Antibodypedia

 DBF4B antibodies

PROTEIN BROWSER
DBF4B-001
DBF4B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBF4B-001
ENSP00000323663
ENST00000315005
Q8NFT6 [Direct mapping]
Protein DBF4 homolog B
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010571 [positive regulation of nuclear cell cycle DNA replication]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016235 [aggresome]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 615 aa
67.2 kDa 		No 0
DBF4B-003
ENSP00000377178
ENST00000393547
Q8NFT6 [Direct mapping]
Protein DBF4 homolog B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010571 [positive regulation of nuclear cell cycle DNA replication]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016235 [aggresome]
GO:0019901 [protein kinase binding]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 431 aa
47.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.