Cell atlas - TREML1 - The Human Protein Atlas

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TREML1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TREML1
Gene description	Triggering receptor expressed on myeloid cells-like 1
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TREML1 (HGNC Symbol)
Synonyms	dJ238O23.3, TLT1
Description	Triggering receptor expressed on myeloid cells-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41149342 - 41154337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161911 (version 83.38)
Entrez gene	340205
UniProt	Q86YW5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YW5
Antibodypedia	TREML1 antibodies

PROTEIN BROWSER

TREML1-001	TREML1-002	TREML1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TREML1-001 ENSP00000402855 ENST00000426005	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	311 aa 32.7 kDa	Yes	1
TREML1-002 ENSP00000400405 ENST00000437044	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	200 aa 20.7 kDa	Yes	1
TREML1-003 ENSP00000362219 ENST00000373127	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	199 aa 21.3 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.