Tissue expression of TREML1 - Summary - The Human Protein Atlas

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TREML1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TREML1
Gene description	Triggering receptor expressed on myeloid cells-like 1
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in megakaryocytes and subtypes of cells in the spleen with positivity in platelets in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA016700 , HPA017860
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)

GENE INFORMATION
Gene name	TREML1 (HGNC Symbol)
Synonyms	dJ238O23.3, TLT1
Description	Triggering receptor expressed on myeloid cells-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41149342 - 41154337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161911 (version 83.38)
Entrez gene	340205
UniProt	Q86YW5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YW5
Antibodypedia	TREML1 antibodies

PROTEIN BROWSER

TREML1-001	TREML1-002	TREML1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TREML1-001 ENSP00000402855 ENST00000426005	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	311 aa 32.7 kDa	Yes	1
TREML1-002 ENSP00000400405 ENST00000437044	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	200 aa 20.7 kDa	Yes	1
TREML1-003 ENSP00000362219 ENST00000373127	Q86YW5 [Direct mapping] Trem-like transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	199 aa 21.3 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.